The COVID-19 pandemic has become a significant burden not only on healthcare professionals providing medical care to patients in conditions of acute nosology. It is obvious that the pathomorphological basis of the immediate and long-term complications of COVID-19, which formed the post-Covid syndrome (PPCS), will continue to grow in the foreseeable future and will become the basis for the formation of many chronic diseases. The direct toxic effect of SARS-CoV-2 causes a disruption of the patient’s immune response, which leads to damage to the airborne barrier; necrosis of tissue structures is a trigger for “reflex” activation of the blood coagulation system - and all together this leads to the development of a “cytokine storm” (CSS). The severity of these processes affects the nature of both the acute course of COVID-19 and subsequent complications and their long-term consequences, including the quality of life of patients after an infection. The physical, cognitive, and neuropsychological consequences of coronavirus infection are increasingly realistic, and associated functional limitations may persist long after hospital discharge, negatively impacting patients' quality of life.
Within the framework of the 22nd European Congress Internal Medicine (6-9 March, Turkey) a discussion took place about the effect of PDRN drug rehabilitation on biomarkers of endothelial dysfunction in patients with PSS (post 1) and neuropsychical status of patients with PSS: ideas for medical rehabilitation (post 2)
Derinat® is an immunomodulatory agent, hemopoiesis stimulator, regenerative and reparative agent.  Derinat® Clinical Efficacy Experience. Prospective Areas of Derinat® Efficacy Studies.
Enhancing the natural reparative effect in damaged tissues, is probably much depends on the activity of macrophages, and has a wide phenotypic plasticity.
Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) – is a widespread viruses that can form a lifelong infection and persistence. Genital herpes in women of childbearing age is a serious risk of vertical transmission from mother to fetus.
Ultraviolet-B (UVB) is one of the most cytotoxic and mutagenic stresses that contribute to skin damage and aging through increasing intracellular Ca2+ and reactive oxygen species (ROS).